Yoda1, a Piezo1 agonist, induced latent HIV reactivation associated with upregulation of CD3/TCR complex and HLA genes

Abstract excerpt

<title>Abstract</title> <p>There is currently no cure for HIV because of the presence of latent viral reservoirs in people with HIV (PWH) on antiretroviral therapy (ART). Latency-reversing agents (LRAs) that can effectively reactivate and destroy latent HIV are being developed as a possible cure for HIV. Here, we identify Yoda1, a Piezo1 agonist, as a novel LRA. Yoda1 reactivated latent HIV in vitro ACH2 cells an...

Topics

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• Anti-HIV Agents
• Antiretroviral Therapy, Highly Active
• Drug Resistance, Viral
• Epigenesis, Genetic
• Gene Expression Regulation, Viral
• HIV/AIDS drug development and treatment
• HIV Research and Treatment
• Protein Degradation and Inhibitors

Identifiers and source

Literature Corpus work

e9f8da25-70e4-5e8e-89dd-5a2bf6becec3

DOI

10.21203/rs.3.rs-6208371/v1