Article
Epigenetic regulation of HIV-1 persistence and evolving strategies for virus eradication.
Sub-cellular biochemistry - 1 Jan 2013
Dhamija Neeru, Rawat Pratima, Mitra Debashis
Abstract excerpt
Despite the intense effort put by researchers globally to understand Human Immunodeficiency Virus (HIV-1) pathogenesis since its discovery 30 years ago, the acquired knowledge till date is not good enough to eradicate HIV-1 from an infected individual. HIV-1 infects cells of the human immune system and integrates into the host cell genome thereby leading to persistent infection in these cells. Based on the...
Topics
- Animals
- Anti-HIV Agents
- Antiretroviral Therapy, Highly Active
- Disease Models, Animal
- Drug Resistance, Viral
- Epigenesis, Genetic
- Gene Expression Regulation, Viral
- Genotype
- HIV Infections
- HIV-1
- Humans