Article

ClonoScreen3D: a novel three-dimensional clonogenic screening platform for identification of radiosensitizers for glioblastoma

2023-10-04

Abstract excerpt

<h4>Purpose</h4> Glioblastoma (GBM) is a lethal brain tumour. Standard of care treatment comprising surgery, radiation and chemotherapy results in median survival rates of 12-15 months. Molecular targeted agents identified using conventional two-dimensional (2D) in vitro models of GBM have failed to improve outcome in patients, rendering such models inadequate for therapeutic target identification. We developed...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4d57e4d0-9d6e-537f-97e7-dea76e3791f9
DOI: 10.1101/2023.10.04.560635

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ClonoScreen3D: a novel three-dimensional clonogenic screening platform for identification of radiosensitizers for glioblastomaDOI 10.1101/2023.10.04.560635Read

ClonoScreen3D-CRISPRi Uncovers Genetic Modifiers of Radiation Response in GlioblastomaSemantic proximity Read

Synergistic Effects of the DRD2/3 Antagonist ONC201 and Radiation in GlioblastomaSemantic proximity Read

Cyclin-dependent kinase inhibitors exert distinct effects on patient-derived 2D and 3D glioblastoma cell culture modelsSemantic proximity Read

Chronically radiation-exposed survivor glioblastoma cells display poor response to Chk1 inhibitionSemantic proximity Read

An in vivo model of glioblastoma radiation resistance identifies long noncoding RNAs and targetable kinasesSemantic proximity Read

Selective Inhibition of Parallel DNA Damage Response Pathways Optimizes Radiosensitization of Glioblastoma Stem-like CellsSemantic proximity Read

A comprehensive pharmacological survey across heterogeneous patient-derived GBM stem cell modelsSemantic proximity Read

Gliamimic: A Longitudinal, Multimodal in Vitro Platform for Evaluating Glioblastoma Treatment Response and Relapse in Patient-derived Organoids or SpheroidsSemantic proximity Read

Impact of accumulated alterations in driver and passenger genes on response to radiation therapy.Semantic proximity Read

A Cytotoxic Three-Dimensional-Spheroid, High-Throughput Assay Using Patient-Derived Glioma Stem CellsSemantic proximity Read

Radiation Responses of 2D and 3D Glioblastoma Cells: A Novel, 3D-specific Radioprotective Role of VEGF/Akt Signaling through Functional Activation of NHEJSemantic proximity Read

The Radiosensitizing Effect of AZD0530 in Glioblastoma and Glioblastoma Stem-Like CellsSemantic proximity Read