Deciphering the involvement of the Hippo pathway co-regulators, YAP/TAZ in invadopodia formation and matrix degradation

Abstract excerpt

<title>Abstract</title> <p>Invadopodia are adhesive, actin-rich protrusions formed by metastatic cancer cells that degrade the extracellular matrix and facilitate invasion. They support the metastatic cascade by a spatially and temporally coordinated process whereby invading cells bind to the matrix, degrade it by specific metalloproteinases, and mechanically penetrate diverse tissue barriers by forming actin-ric...

Topics

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• Cancer Cells and Metastasis
• Cell Adhesion Molecules Research
• Cell Image Analysis Techniques
• Cellular Mechanics and Interactions
• Extracellular Matrix
• Protease and Inhibitor Mechanisms
• Signaling Pathways in Disease
• TGF-β signaling in diseases

Identifiers and source

Literature Corpus work

e9f310d5-b601-545d-b827-5c7b312722ad

DOI

10.21203/rs.3.rs-1948766/v1