Article

Deciphering the involvement of the Hippo pathway co-regulators, YAP/TAZ in invadopodia formation and matrix degradation

2022-07-01

Abstract excerpt

Invadopodia are adhesive, actin-rich protrusions, formed by metastatic cancer cells that degrade the extracellular matrix and facilitate invasion. They support the metastatic cascade by a spatially and temporally coordinated process whereby invading cells bind to the matrix, degrade it by specific metalloproteinases, and mechanically penetrate diverse tissue barriers by forming actin-rich extensions. However, desp...

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Identifiers and source

Literature Corpus work: ce55c488-07ee-553d-ac18-76d6ce9db94a
DOI: 10.1101/2022.06.28.497902

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