Article
Functional variants of human papillomavirus type 16 demonstrate host genome integration and transcriptional alterations corresponding to their unique cancer epidemiology.
BMC genomics - 2 Nov 2016
Jackson Robert, Rosa Bruce A, Lameiras Sonia, Cuninghame Sean, Bernard Josee, Floriano Wely B, Lambert Paul F, Nicolas Alain, Zehbe Ingeborg
Abstract excerpt
BACKGROUND: Human papillomaviruses (HPVs) are a worldwide burden as they are a widespread group of tumour viruses in humans. Having a tropism for mucosal tissues, high-risk HPVs are detected in nearly all cervical cancers. HPV16 is the most common high-risk type but not all women infected with high-risk HPV develop a malignant tumour. Likely relevant, HPV genomes are polymorphic and some HPV16 single nucleotide...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.