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Article

Growth Differentiation Factor 15 as a Novel Biomarker for Metformin.

Diabetes care - 1 Feb 2017

Gerstein Hertzel C, Pare Guillaume, Hess Sibylle, Ford Rebecca J, Sjaarda Jennifer, Raman Kripa, McQueen Matthew, Lee ShunFu, Haenel Heinz, Steinberg Gregory R

Abstract excerpt

OBJECTIVE: Metformin is a commonly used glucose-lowering drug. However, apart from glycemic measures, no biomarker for its presence or dose has been identified. RESEARCH DESIGN AND METHODS: A total of 237 biomarkers were assayed in baseline serum from 8,401 participants (2,317 receiving metformin) in the Outcome Reduction with Initial Glargine Intervention (ORIGIN) trial. Regression models were used to identify...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Diabetes Mellitus, Type 2

Share to Dose-Response Relationship, Drug

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Source

Identifiers

PMID: 27974345
DOI: 10.2337/dc16-1682

Genes

GDF15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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