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Investigation of the genetic architecture of cam morphology, and its relationship with hip osteoarthritis, using alpha angle as a proxy measure

2022-07-22

Abstract excerpt

<h4>Objectives</h4> To examine the genetic architecture of cam morphology, using alpha angle (AA) as a proxy measure, we conducted an AA genome wide association study (GWAS), followed by Mendelian randomisation (MR) to evaluate its causal relationship with hip osteoarthritis (HOA). <h4>Methods</h4> Observational analyses examined associations between AA derived from hip DXA scans in UK Biobank (UKB), and radiograp...

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Literature Corpus work
07aff4af-8f0d-5e1e-ab09-d4ae131ee77b
DOI
10.1101/2022.07.22.22277884
Open publication

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