Spatiotemporal genomic architecture informs precision oncology in glioblastoma.

doi:10.1038/ng.3806

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Article

Spatiotemporal genomic architecture informs precision oncology in glioblastoma.

Nature genetics - 1 Apr 2017

Lee Jin-Ku, Wang Jiguang, Sa Jason K, Ladewig Erik, Lee Hae-Ock, Lee In-Hee, Kang Hyun Ju, Rosenbloom Daniel S, Camara Pablo G, Liu Zhaoqi, van Nieuwenhuizen Patrick, Jung Sang Won, Choi Seung Won, Kim Junhyung, Chen Andrew, Kim Kyu-Tae, Shin Sang, Seo Yun Jee, Oh Jin-Mi, Shin Yong Jae, Park Chul-Kee, Kong Doo-Sik, Seol Ho Jun, Blumberg Andrew, Lee Jung-Il, Iavarone Antonio, Park Woong-Yang, Rabadan Raul, Nam Do-Hyun

Abstract excerpt

Precision medicine in cancer proposes that genomic characterization of tumors can inform personalized targeted therapies. However, this proposition is complicated by spatial and temporal heterogeneity. Here we study genomic and expression profiles across 127 multisector or longitudinal specimens from 52 individuals with glioblastoma (GBM). Using bulk and single-cell data, we find that samples from the same tumor...

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Identifiers

PMID: 28263318
DOI: 10.1038/ng.3806
PMCID: PMC5627771

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