Article

OPA1 drives ROS-dependent neutrophil extracellular trap formation to promote tumor immunotherapy resistance

2026-05-29

Abstract excerpt

<title>Abstract</title> <p> Immune checkpoint blockade targeting PD-1 has transformed oncology by reactivating antitumor immunity yet only a subset of patients derives durable benefit. Although neutrophil extracellular traps (NETs) contribute to tumor immune escape and immunotherapy resistance, the upstream key regulator and precise mechanism remain unknown. Here, we revealed that NETs were significantly enriche...

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Literature Corpus work: e9723445-0d09-5ed6-b762-8c530b9e0325
DOI: 10.21203/rs.3.rs-9625009/v1

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