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Article

Neutrophil Extracellular Traps Promote T Cell Exhaustion in the Tumor Microenvironment.

Frontiers in immunology - 1 Jan 2021

Kaltenmeier Christof, Yazdani Hamza O, Morder Kristin, Geller David A, Simmons Richard L, Tohme Samer

Abstract excerpt

While neutrophil extracellular traps (NETs) are important for directly promoting cancer growth, little is known about their impact on immune cells within the tumor microenvironment (TME). We hypothesize that NETs can directly interact with infiltrating T cells to promote an immunosuppressive TME. Herein, to induce a NET-rich TME, we performed liver Ischemia/Reperfusion (I/R) in an established cancer metastasis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34899751
DOI: 10.3389/fimmu.2021.785222
PMCID: PMC8652262

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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