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Article

Base-Edited CAR7 T Cells for Relapsed T-Cell Acute Lymphoblastic Leukemia

14 Jun 2023

Abstract excerpt

BACKGROUND: Cytidine deamination that is guided by clustered regularly interspaced short palindromic repeats (CRISPR) can mediate a highly precise conversion of one nucleotide into another - specifically, cytosine to thymine - without generating breaks in DNA. Thus, genes can be base-edited and rendered inactive without inducing translocations and other chromosomal aberrations. The use of this technique in...

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PMID: 37314354
DOI: 10.1056/nejmoa2300709

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