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Sequentially Self-Assembled Supramolecular Nanocomplexes Enable Systemic Cas9 RNP Delivery and <i>In Vivo</i> Tumor Genome Editing

2026-05-12

Abstract excerpt

<h4>ABSTRACT</h4> In vivo genome editing with CRISPR–Cas9 ribonucleoproteins (RNPs) holds substantial therapeutic promise, yet rapid bloodstream clearance and the absence of delivery systems capable of systemic tumor targeting have hindered its clinical translation. Herein, a supramolecular ternary complex platform is reported in which Cas9/sgRNA RNPs are co-assembled with tannic acid (TA) and phenylboronic acid...

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Literature Corpus work
e950f002-2a01-5413-824e-8ca25158eb31
DOI
10.64898/2026.05.08.723716
Open publication

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Sequentially Self-Assembled Supramolecular Nanocomplexes Enable Systemic Cas9 RNP Delivery and <i>In Vivo</i> Tumor Genome EditingDOI 10.64898/2026.05.08.723716
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