Sequentially Self-Assembled Supramolecular Nanocomplexes Enable Systemic Cas9 RNP Delivery and In Vivo Tumor Genome Editing

Abstract excerpt

<title>Abstract</title> <p> <italic>In vivo</italic> genome editing with CRISPR–Cas9 ribonucleoproteins (RNPs) holds substantial therapeutic promise, yet rapid bloodstream clearance and the absence of delivery systems capable of systemic tumor targeting have hindered its clinical translation. Herein, a supramolecular ternary complex platform is reported in which Cas9/sgRNA RNPs are co-assembled with tannic acid...

Topics

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• Advanced biosensing and bioanalysis techniques
• CAR-T cell therapy research
• CRISPR and Genetic Engineering
• Mosquito-borne diseases and control
• RNA Interference and Gene Delivery
• Viral Infections and Immunology Research

Identifiers and source

Literature Corpus work

273ad032-06ac-52bd-a00c-42932ca70a59

DOI

10.21203/rs.3.rs-9977199/v1