Article
A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Cell systems - 25 Jan 2017
Seyfried Nicholas T, Dammer Eric B, Swarup Vivek, Nandakumar Divya, Duong Duc M, Yin Luming, Deng Qiudong, Nguyen Tram, Hales Chadwick M, Wingo Thomas, Glass Jonathan, Gearing Marla, Thambisetty Madhav, Troncoso Juan C, Geschwind Daniel H, Lah James J, Levey Allan I
Abstract excerpt
Here, we report proteomic analyses of 129 human cortical tissues to define changes associated with the asymptomatic and symptomatic stages of Alzheimer's disease (AD). Network analysis revealed 16 modules of co-expressed proteins, 10 of which correlated with AD phenotypes. A subset of modules overlapped with RNA co-expression networks, including those associated with neurons and astroglial cell types, showing...
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