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Article

Nascent Transcriptomics Reveal Cellular Prolytic Factors Upregulated Upstream of the Latent-to-Lytic Switch Protein of Epstein-Barr Virus.

Journal of virology - 17 Mar 2020

Frey Tiffany R, Brathwaite Jozan, Li Xiaofan, Burgula Sandeepta, Akinyemi Ibukun A, Agarwal Saurabh, Burton Eric M, Ljungman Mats, McIntosh Michael T, Bhaduri-McIntosh Sumita

Abstract excerpt

Lytic activation from latency is a key transition point in the life cycle of herpesviruses. Epstein-Barr virus (EBV) is a human herpesvirus that can cause lymphomas, epithelial cancers, and other diseases, most of which require the lytic cycle. While the lytic cycle of EBV can be triggered by chemicals and immunologic ligands, the lytic cascade is activated only when expression of the EBV latent-to-lytic switch...

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Share to Gene Expression Regulation, Viral
Share to Herpesvirus 4, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31941784
DOI: 10.1128/JVI.01966-19
PMCID: PMC7081890

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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