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Probing intratumoral metabolic compartmentalisation in fumarate hydratase-deficient renal cancer using clinical hyperpolarised<sup>13</sup>C-MRI and mass spectrometry imaging

2024-05-08

Abstract excerpt

<h4>Background</h4> Fumarate hydratase-deficient renal cell carcinoma (FHd-RCC) is a rare and aggressive renal cancer subtype characterised by increased fumarate accumulation and upregulated lactate production. Renal tumours demonstrate significant intratumoral metabolic heterogeneity, which may contribute to treatment failure. Emerging non-invasive metabolic imaging techniques have clinical potential to more accu...

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Literature Corpus work
e8dacec9-d5f6-55a0-a140-754f9ce2ecc4
DOI
10.1101/2024.05.06.24306817
Open publication

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