Article

Topoisomerase 2β induces DNA breaks to regulate human papillomavirus replication

2021-01-08

Abstract excerpt

Topoisomerases regulate higher order chromatin structures through the transient breaking and re-ligating of one or both strands of the phosphodiester backbone of duplex DNA. TOP2β is a type II topoisomerase that induces double strand DNA breaks at topological-associated domains (TADS) to relieve torsional stress arising during transcription or replication. TADS are anchored by CTCF and SMC1 cohesin proteins in com...

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Literature Corpus work: e8b6efb4-8eba-528c-9e84-5de00a5687bc
DOI: 10.1101/2021.01.07.425831

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