Article

Association of RhoGEF Ect2 with Desmoplakin Supports RhoA Activity at Intercellular Junctions: Implications for Carvajal Disease

2025-05-24

Abstract excerpt

Desmoplakin (DP) is an essential component of the desmosomal adhesion complex, tethering intermediate filaments to sites of intercellular adhesion to confer mechanical integrity to tissues. As a frequent target for mutation in cardiocutaneous syndromes that vary widely in phenotype, DP’s roles as a signaling hub are rapidly emerging. Here, we identify the RhoGEF Ect2 as a previously unappreciated binding partner o...

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Literature Corpus work: 6e266a11-b45e-5b6d-9f21-3284de240827
DOI: 10.1101/2025.05.21.655405

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