Article

Pathway-centric multi-omics and functional precision medicine reveal shared drug vulnerabilities in heterogeneous adult Wilms tumor

2026-06-25

Abstract excerpt

<h4>ABSTRACT</h4> Wilms tumor, i.e., nephroblastoma, is rare in adults and lacks standardized treatment, complicating clinical decision-making. Within the functional precision medicine study (DEDUCER), we profiled two spatially distinct tumor regions (T1 and T2) of an adult Wilms tumor patient using integrated histopathology, whole-exome sequencing, FFPE transcriptomics, and ex vivo drug screening of short-term...

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Literature Corpus work: 4305b9bc-da8d-5acf-a3d4-9ff0f150516e
DOI: 10.64898/2026.06.23.734042

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