Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of MANF Causes Childhood-Onset Syndromic Diabetes Due to Increased Endoplasmic Reticulum Stress.

Diabetes - 1 Apr 2021

Montaser Hossam, Patel Kashyap A, Balboa Diego, Ibrahim Hazem, Lithovius Väinö, Näätänen Anna, Chandra Vikash, Demir Korcan, Acar Sezer, Ben-Omran Tawfeg, Colclough Kevin, Locke Jonathan M, Wakeling Matthew, Lindahl Maria, Hattersley Andrew T, Saarimäki-Vire Jonna, Otonkoski Timo

Abstract excerpt

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER)-resident protein that plays a crucial role in attenuating ER stress responses. Although MANF is indispensable for the survival and function of mouse β-cells, its precise role in human β-cell development and function is unknown. In this study, we show that lack of MANF in humans results in diabetes due to increased ER...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endoplasmic Reticulum Stress
Share to Enzyme-Linked Immunosorbent Assay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Flow Cytometry

Share to Gene Editing

Share to Glucose Tolerance Test

Share to Nerve Growth Factors

Share to Real-Time Polymerase Chain Reaction

Share to Streptozocin

Source

Open in PubMed Open full text

Identifiers

PMID: 33500254
DOI: 10.2337/db20-1174
PMCID: PMC7610619

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of MANF Causes Childhood-Onset Syndromic Diabetes Due to Increased Endoplasmic Reticulum Stress.PMID 33500254Read ↗

Dual Role of Neuroplastin in Pancreatic β Cells: Regulating Insulin Secretion and Promoting Islet InflammationSemantic proximity Read ↗

Deficiency of Mesencephalic Astrocyte-derived Neurotrophic Factor Aggravates Acute Pancreatitis in MiceSemantic proximity Read ↗

In vivo cellular adaptation to ER stress: survival strategies with double-edged consequences.Semantic proximity Read ↗

Exploring the Conserved Role of MANF in the Unfolded Protein Response in Drosophila melanogaster.Semantic proximity Read ↗

Conserved Roles of <i>C. elegans</i> and Human MANFs in Sulfatide Binding and CytoprotectionSemantic proximity Read ↗

YIPF5 mutations cause neonatal diabetes and microcephaly through endoplasmic reticulum stress.Semantic proximity Read ↗

The protective role of mesencephalic astrocyte-derived neurotrophic factor in endoplasmic reticulum stress in RT4-D6P2T schwannoma sells with the S63del MPZ mutation.Semantic proximity Read ↗

Myt Transcription Factors prevent stress-response gene over-activation to enable postnatal pancreatic β cell proliferation and functionSemantic proximity Read ↗

Adult mouse eIF2Bε Arg191His astrocytes display a normal integrated stress response in vitro.Semantic proximity Read ↗

A Point Mutation in Translation Initiation Factor 2B Leads to a Continuous Hyper Stress State in Oligodendroglial-Derived CellsSemantic proximity Read ↗

ER stress and cell fate: FKBP2 regulates proinsulin folding and α- vs. β cell differentiation via NFAT and HDAC9Semantic proximity Read ↗

Gene supplementation in Vanishing White Matter mice ameliorates the diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.