Article

Non-glycosylated Seipin to Cause a Motor Neuron Disease Induces ER stress and Apoptosis by Inactivating the ER Calcium Pump SERCA2b

2021-10-23

Abstract excerpt

<h4>ABSTRACT</h4> A causal relationship between endoplasmic reticulum (ER) stress and the development of neurodegenerative diseases remains controversial. Here, we focused on Seipinopathy, a dominant motor neuron disease, based on the finding that its causal gene product, Seipin, is a hairpin-like transmembrane protein in the ER. Gain-of-function mutations of Seipin produce non-glycosylated Seipin (ngSeipin), whi...

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Literature Corpus work: 6d2d40bb-0848-5dfe-be6a-ef185207f2ba
DOI: 10.1101/2021.10.22.465502

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