Article

Natural evolution mechanisms of the IDH mutant glioma revealed by multi-omics sequencing of a long-term survivor

2021-03-04

Abstract excerpt

<title>Abstract</title> <p><bold>Purpose</bold> Low-grade gliomas(LGG) almost invariably progress into secondary glioblastoma with limited therapeutic options. The currently proposed progression mechanisms were mainly based on treatment intervened patients, seldom is known about the mechanisms under natural evolution.<bold>Methods</bold> A high-grade glioblastoma (G4) occurred at the posterior of the primary LGG...

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Literature Corpus work: e895f3e6-2d6d-5869-9565-b9e6ff6b4fd1
DOI: 10.21203/rs.3.rs-281275/v1

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