Article

Transactive response DNA-binding Protein (TDP-43) regulates early HIV-1 entry and infection

2021-12-07

Abstract excerpt

The transactive response DNA-binding protein (TDP-43) is an important regulator of mRNA, being reported to stabilize the anti-HIV factor, histone deacetylase 6 (HDAC6). However, little is known about the role of TDP-43 in HIV infection. In this work, we seek for the TDP-43 function on regulating CD4+ T cell permissibility to HIV infection. We observed that over-expression of wt-TDP-43 in CD4+ T cells stabilized HD...

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Literature Corpus work: e87fb8b8-c4cf-5cfe-8898-8bbba34a28cd
DOI: 10.1101/2021.12.06.471424

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