Article

Divide et Impera: Identification of Small-Molecule Inhibitors of HCMV Replication Interfering with Dimerization of DNA Polymerase Processivity Factor UL44

2020-02-10

Abstract excerpt

<h4>ABSTRACT</h4> Human cytomegalovirus (HCMV) is a leading cause of severe diseases in immunocompromised individuals, including AIDS and transplanted patients, and in congenitally infected newborns. Despite the availability of several antiviral drugs, their utility is limited by poor bioavailability, toxicity, and resistant strains emergence. Therefore, it is crucial to identify new targets of therapeutic interv...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8d346c58-b23c-589c-9d6a-2c5c0f94ed63
DOI: 10.1101/2020.02.06.938233

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Divide et Impera: Identification of Small-Molecule Inhibitors of HCMV Replication Interfering with Dimerization of DNA Polymerase Processivity Factor UL44DOI 10.1101/2020.02.06.938233Read

Divide et Impera: An In Silico Screening Targeting HCMV ppUL44 Processivity Factor Homodimerization Identifies Small Molecules Inhibiting Viral ReplicationSemantic proximity Read

Human Cytomegalovirus UL78 is a Nuclear-Localized GPCR Necessary for Efficient Reactivation from Latent Infection in CD34 <sup>+</sup> Hematopoietic Progenitor CellsSemantic proximity Read

Understanding and exploiting viral protein US28 during human cytomegalovirus latencySemantic proximity Read

Role of homodimerization of human cytomegalovirus DNA polymerase accessory protein UL44 in origin-dependent DNA replication in cells.Semantic proximity Read

Deciphering letermovir's mode of action and resistance mutation effects.Semantic proximity Read

Binding parameters and thermodynamics of the interaction of the human cytomegalovirus DNA polymerase accessory protein, UL44, with DNA: implications for the processivity mechanismSemantic proximity Read

The Flexible Loop of the Human Cytomegalovirus DNA Polymerase Processivity Factor ppUL44 Is Required for Efficient DNA Binding and Replication in CellsSemantic proximity Read

Generation of a panel of mutants that are resistant to standard of care therapies in a clinically relevant strain of human cytomegalovirus for drug resistance profiling.Semantic proximity Read

The human cytomegalovirus terminase complex as an antiviral target: a close-up viewSemantic proximity Read

Residues of human cytomegalovirus DNA polymerase catalytic subunit UL54 that are necessary and sufficient for interaction with the accessory protein UL44.Semantic proximity Read

Epigenetically repressing human cytomegalovirus lytic infection and reactivation from latency in THP-1 model by targeting H3K9 and H3K27 histone demethylasesSemantic proximity Read

Structure and inhibition of herpesvirus DNA packaging terminase nuclease domain.Semantic proximity Read