Article

TDP-43 promotes efficient HSV-1 replication in human DRG-derived neurons

2025-07-08

Abstract excerpt

<h4>ABSTRACT</h4> TAR DNA-binding protein 43 (TDP-43) is a versatile nuclear RNA-binding protein that performs important functions in RNA localization, processing and stability. In the neurodegenerative disease amyotrophic lateral sclerosis (ALS) TDP-43 forms toxic, insoluble cytoplasmic aggregates that ultimately lead to neuronal loss. Although TDP-43 is expressed in every cell type, its function and subcellular...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0b2afd24-9115-5409-99b7-974e1fc7f702
DOI: 10.1101/2025.07.08.662712

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TDP-43 promotes efficient HSV-1 replication in human DRG-derived neuronsDOI 10.1101/2025.07.08.662712Read

Implications of TDP-43 in non-neuronal systemsSemantic proximity Read

Decoding TDP-43: the molecular chameleon of neurodegenerative diseasesSemantic proximity Read

Familial ALS/FTD-associated RNA-Binding deficient TDP-43 mutants cause neuronal and synaptic transcript dysregulation <i>in vitro</i>Semantic proximity Read

Familial ALS/FTD-associated RNA-binding deficient TDP-43 mutants cause neuronal and synaptic transcript dysregulation in vitroSemantic proximity Read

Reviewing the Potential Links between Viral Infections and TDP-43 ProteinopathiesSemantic proximity Read

TDP-43 directly inhibits RNA accumulation in neurites through modulation of RNA stabilitySemantic proximity Read

Understanding age-related pathologic changes in TDP-43 functions and the consequence on RNA splicing and signalling in health and diseaseSemantic proximity Read

Neurodegeneration in human brain organoids infected with herpes simplex virus type 1Semantic proximity Read

TDP-43 regulates endogenous retrovirus-K viral protein accumulation.Semantic proximity Read

TDP-43 dysfunction results in R-loop accumulation and DNA replication defectsSemantic proximity Read

Maintenance of neuronal TDP-43 expression requires axonal lysosome transportSemantic proximity Read

Novel and known transcriptional targets of ALS/FTD protein TDP-43: Meta-analysis and interactive graphical databasesSemantic proximity Read