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Integrative computational analysis prioritizes ERBB2 within a tert- butylhydroquinone–neuroblastoma network

2026-08-22

Abstract excerpt

<title>Abstract</title> <p>Background Tert-butylhydroquinone (TBHQ) is a redox-active food antioxidant, but its relationship to neuroblastoma (NB) remains uncertain. We integrated network toxicology, disease transcriptomics, structural modeling, and clinical cohort analyses to prioritize testable TBHQ–NB hypotheses. Methods We intersected 119 TBHQ-related targets with 2,105 NB-associated genes. The 55 shared ta...

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Literature Corpus work
e8680f63-6ca0-5a86-9a1d-1ade39b1e9d8
DOI
10.21203/rs.3.rs-10550308/v1
Open publication

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