Article

Glucocorticoid chrono-pharmacology unveils novel targets for the cardiomyocyte-specific GR-KLF15 axis in cardiac glucose metabolism

2023-12-18

Abstract excerpt

<h4>ABSTRACT</h4> Circadian time-of-intake gates the cardioprotective effects of glucocorticoid administration in both healthy and infarcted hearts. The cardiomyocyte-specific glucocorticoid receptor (GR) and its co-factor, Krüppel-like factor (Klf15), play critical roles in maintaining normal heart function in the long-term and serve as pleiotropic regulators of cardiac metabolism. Despite this understanding, th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 295598a2-c0d0-56ef-a07a-7775d4789efc
DOI: 10.1101/2023.12.18.572210

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Glucocorticoid chrono-pharmacology unveils novel targets for the cardiomyocyte-specific GR-KLF15 axis in cardiac glucose metabolismDOI 10.1101/2023.12.18.572210Read

Constitutive expression of cardiomyocyte Klf9 precipitates metabolic dysfunction and spontaneous heart failureSemantic proximity Read

Glucocorticoid receptor epigenetic activity in the heartSemantic proximity Read

A cross-tissue transcriptomic approach decodes glucocorticoid receptor-dependent links to human metabolic phenotypesSemantic proximity Read

Glucocorticoid Signaling and the Aging HeartSemantic proximity Read

Glucocorticoid Receptor‐Binding and Transcriptome Signature in CardiomyocytesSemantic proximity Read

Cardiomyocyte PGC-1α enables physiological adaptations to endurance exercise through suppression of GDF15 and cardiac atrophySemantic proximity Read

Glucocorticoid Signaling in Health and Disease: Insights From Tissue-Specific GR Knockout MiceSemantic proximity Read

A novel serum glucocorticoid regulated kinase 1 inhibitor improves cardiac structure and function in heart failureSemantic proximity Read

The evolving systemic biomarker milieu in obese ZSF1 rat model of human cardiometabolic syndrome: Characterization of the model and cardioprotective effect of GDF15Semantic proximity Read

KLF15 Establishes the Landscape of Diurnal Expression in the HeartSemantic proximity Read

Metabolic reprogramming via PPARα signaling in cardiac hypertrophy and failure: From metabolomics to epigeneticsSemantic proximity Read

The human genetic variant rs6190 unveils Foxc1 and Arid5a as novel pro-metabolic targets of the glucocorticoid receptor in muscleSemantic proximity Read