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A structure and evolutionary-based classification of solute carriers

8 Sept 2022

Abstract excerpt

Solute carriers are an operationally defined diverse family of membrane proteins involved in the transport of nutrients, metabolites, xenobiotics, and drugs. Here, we provide an integrative classification of solute carriers by combining evolutionary information with proteome-wide structure models recently made available through the AlphaFold resource. Analyses of orthologous relations among 455 protein-coding...

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PMID: 36164651
DOI: 10.1016/j.isci.2022.105096

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