Article

Quantitatively Correlating interactions between three intrinsic kinetic processes to in vivo protein kinase occupancy

2024-01-31

Abstract excerpt

<h4>Background: </h4> and Purpose: Excellent drug therapy is usually characterized by longer duration with sufficiently high occupancy on desired target. Except for classical pharmacokinetics (PK) contribution, binding kinetics (BK) and target kinetics (TK) are emerging as key role. This study aims to establish mathematical simulation model of kinase target engagement by integrating three intrinsic kinetic process...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e81e9c9b-e056-5b73-9665-ce04ed2caf8b
DOI: 10.22541/au.170668228.81827497/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Quantitatively Correlating interactions between three intrinsic kinetic processes to in vivo protein kinase occupancyDOI 10.22541/au.170668228.81827497/v1Read

Kinetic Fingerprints as Mechanistic and Clinical Roadmaps Across KIT Activation StatesSemantic proximity Read

A Novel High-Throughput FLIPR Tetra Based Method for Capturing Highly Confluent Kinetic Data for Structure-Kinetic Relationship Guided Early Drug DiscoverySemantic proximity Read

Integrated Single-Dose Kinome Profiling Data is Predictive of Cancer Cell Line Sensitivity to Kinase InhibitorsSemantic proximity Read

Simulating BRAFV600E-MEK-ERK signalling dynamics in response to vertical inhibition treatment strategies.Semantic proximity Read

Systematic Evaluation of High-Throughput PBK Modelling Strategies for the Prediction of Intravenous and Oral Pharmacokinetics in HumansSemantic proximity Read

In vitro PK/PD modeling of tyrosine kinase inhibitors in non-small cell lung cancer cell lines.Semantic proximity Read

Molecular conformations, interactions, and properties associated with drug efficiency and clinical performance among VEGFR TK inhibitorsSemantic proximity Read

Data-Driven Mechanistic Computational Modeling of Human Cell Cycle Phases for Defining Inhibitor Combinations in SilicoSemantic proximity Read

Insights into the binding mode of MEK type-III inhibitors. A step towards discovering and designing allosteric kinase inhibitors across the human kinomeSemantic proximity Read

Illuminating kinase inhibitors biology by cell signaling profilingSemantic proximity Read

Incorporating Receptor Theory in Mechanism-Based Pharmacokinetic-Pharmacodynamic (PK-PD) ModelingSemantic proximity Read

Beyond IC50-A computational dynamic model of drug resistance in enzyme inhibition treatment.Semantic proximity Read