Article

A Novel High-Throughput FLIPR Tetra Based Method for Capturing Highly Confluent Kinetic Data for Structure-Kinetic Relationship Guided Early Drug Discovery

2020-12-08

Abstract excerpt

Target engagement by small-molecules is necessary for producing a physiological outcome. In the past, a lot of emphasis was placed on understanding the thermodynamics of such interactions to guide structure-activity relationship. However, it is becoming clearer that understanding the kinetics of the interaction between a small molecule inhibitor and the biological target (structure kinetic relationship, SKR)...

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Literature Corpus work: a290076a-be11-520c-abc4-f40a972d3516
DOI: 10.26434/chemrxiv.13347524.v1

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