Article

Structural features of mTORC2 that control substrate-specific activities

2022-02-03

Abstract excerpt

mTORC2 is a multi-subunit kinase complex that is central to multiple essential signaling pathways. Two core subunits, Rictor and mSin1 distinguish it from its relative, mTORC1 and support context-dependent phosphorylation of its substrates. mTORC2 structures have been determined previously, however, important questions remain, particularly regarding structural determinants of substrate specificity and context depe...

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Literature Corpus work: e810fb2c-ea49-5714-b49e-c912fae60005
DOI: 10.1101/2022.02.03.478898

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