Article

Targeting pathogenic VWF/ADAMTS13 dysregulation attenuates CTEPH progression

2026-06-22

Abstract excerpt

Chronic thromboembolic pulmonary hypertension (CTEPH) is a life-threatening pulmonary vascular disease, characterized by persistent thrombotic obstruction and progressive pulmonary vascular remodeling, yet the molecular mechanisms linking persistent thrombosis to vascular remodeling remain incompletely understood. Clinical studies have reported elevated plasma von Willebrand factor (VWF) levels and reduced ADAMTS1...

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Literature Corpus work: e7ecc094-09db-51f0-91b2-7114901a88a2
DOI: 10.64898/2026.06.17.732997

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