Article
From thrombosis to fibrosis in chronic thromboembolic pulmonary hypertension.
Thrombosis and haemostasis - 3 Apr 2017
Bochenek Magdalena L, Rosinus Nico S, Lankeit Mareike, Hobohm Lukas, Bremmer Felix, Schütz Eva, Klok Frederikus A, Horke Sven, Wiedenroth Christoph B, Münzel Thomas, Lang Irene M, Mayer Eckhard, Konstantinides Stavros, Schäfer Katrin
Abstract excerpt
The pathomechanisms underlying the development of thrombofibrotic pulmonary artery occlusions in Chronic Thromboembolic Pulmonary Hypertension (CTEPH) are largely unknown. The aim of this study was to allocate distinct cellular processes playing a role in thrombus resolution, such as inflammation, hypoxia, proliferation, apoptosis and angiogenesis, to different stages of thrombofibrotic remodelling. A total of...
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