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Article

Genetic and Clinical Determinants of Chronic Thromboembolic Pulmonary Hypertension: The Role of PAI-1 Polymorphism.

International journal of molecular sciences - 12 Jan 2026

Batum Özgür, Ayık Türk Merve, Varol Yelda, Özyılmaz Berk, Akarçay Alp Eren, Dirican Nigar, Doruk Sibel, Deniz Sami

Abstract excerpt

Chronic thromboembolic pulmonary disease (CTEPD) is a severe long-term complication of acute pulmonary thromboembolism (PTE). Its pathogenesis is multifactorial, involving incomplete thrombus resolution, hemodynamic burden, comorbidities, and genetic factors. However, the contribution of inherited thrombophilic mutations to CTEPD development remains controversial. This retrospective cohort study included 204...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypertension, Pulmonary

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Plasminogen Activator Inhibitor 1

Share to Polymorphism, Genetic

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Source

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Identifiers

PMID: 41596405
DOI: 10.3390/ijms27020758
PMCID: PMC12841476

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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