Article
Activated Endothelial TGFβ1 Signaling Promotes Venous Thrombus Nonresolution in Mice Via Endothelin-1: Potential Role for Chronic Thromboembolic Pulmonary Hypertension.
Circulation research - 17 Jan 2020
Bochenek Magdalena L, Leidinger Christiane, Rosinus Nico S, Gogiraju Rajinikanth, Guth Stefan, Hobohm Lukas, Jurk Kerstin, Mayer Eckhard, Münzel Thomas, Lankeit Mareike, Bosmann Markus, Konstantinides Stavros, Schäfer Katrin
Abstract excerpt
RATIONALE: Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by defective thrombus resolution, pulmonary artery obstruction, and vasculopathy. TGFβ (transforming growth factor-β) signaling mutations have been implicated in pulmonary arterial hypertension, whereas the role of TGFβ in the pathophysiology of CTEPH is unknown. OBJECTIVE: To determine whether defective TGFβ signaling in...
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