Article

VEGFA critically controls neurovascular invasion and chronic low back pain during intervertebral disc degeneration

2025-06-07

Abstract excerpt

Despite its enormous burden on patients and society, chronic low back pain (LBP) has no effective therapeutic options. Innervation of the degenerating intervertebral disc (IVD) is suspected to cause discogenic LBP, but the mechanisms that orchestrate the IVD’s neo-innervation and subsequent symptoms of LBP remain unknown. We hypothesize that Vascular Endothelial Growth Factor-A (VEGFA) critically mediates the neur...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e7c9844f-83c0-5554-a088-2fc67fa9bc1f
DOI: 10.1101/2025.06.03.657641

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

VEGFA critically controls neurovascular invasion and chronic low back pain during intervertebral disc degenerationDOI 10.1101/2025.06.03.657641Read

Decoding the intervertebral disc: Unravelling the complexities of cell phenotypes and pathways associated with degeneration and mechanotransduction.Semantic proximity Read

Machine learning-based diagnostic model of lymphatics-associated genes for new therapeutic target analysis in intervertebral disc degenerationSemantic proximity Read

Nuclear Factor Kappa B Over-Activation in the Intervertebral Disc Leads to Macrophage Recruitment and Severe Disc DegenerationSemantic proximity Read

Current Insights Into the Maintenance of Structure and Function of Intervertebral Disc: A Review of the Regulatory Role of Growth and Differentiation Factor-5Semantic proximity Read

Neuroimmune changes underscore pain-associated behaviors and disc herniations in SM/J miceSemantic proximity Read

Prevention of lumbar disc degeneration through co-manipulation of insulin-like growth factor 1 and vascular endothelial growth factorSemantic proximity Read

Protocol for disease-oriented Russian disc degeneration study (RuDDS) biobank facilitating functional omics studies of lumbar disc degenerationSemantic proximity Read

Single-cell characterization of the human C2 dorsal root ganglion recovered from C1-2 arthrodesis surgery: implications for neck painSemantic proximity Read

HMGB1 mediates macrophage recruitment and regional intervertebral disc tissue functional and mechanical property changes following injurySemantic proximity Read

Role of the miR-133a-5p/FBXO6 axis in the regulation of intervertebral disc degenerationSemantic proximity Read

Genetic Therapy for Intervertebral Disc DegenerationSemantic proximity Read

A Porcine Model of Intervertebral Disc Injury Recapitulates Human Discogenic Pain via Notochordal Cell Loss and Pain-inducing Nucleus Pulposus Cell EmergenceSemantic proximity Read