Article

CXCL12/CXCR4 Governs Lymphatic Valve Formation Through Flow Dependent AKT/FOXO1/FOXC2 Activation

2026-07-22

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Lymphatic valves are specialized structures within lymphatic vessels that ensure unidirectional lymph transport. Defective lymphatic valve formation is associated with lymphedema, a chronic disease characterized by impaired lymph drainage and the accumulation of protein-rich interstitial fluid. Lymphatic valves form during late embryonic stages in mice, with oscillatory shea...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e02fb2b9-0f58-5d78-985e-7da12d7819d6
DOI: 10.64898/2026.07.21.739861

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CXCL12/CXCR4 Governs Lymphatic Valve Formation Through Flow Dependent AKT/FOXO1/FOXC2 ActivationDOI 10.64898/2026.07.21.739861Read

FOXO1 represses lymphatic valve formation and maintenance via PRDM1Semantic proximity Read

Foxo1 deletion promotes the growth of new lymphatic valvesSemantic proximity Read

ORAI1 Activates Proliferation of Lymphatic Endothelial Cells in Response to Laminar Flow Through Krüppel-Like Factors 2 and 4.Semantic proximity Read

Lymphatic vessel development: fluid flow and valve-forming cells.Semantic proximity Read

Rictor induces AKT signaling to regulate lymphatic valve formationSemantic proximity Read

A neuro-lymphatic communication guides lymphatic development by CXCL12 and CXCR4 signalingSemantic proximity Read

Endothelial Nitric Oxide Synthase Regulates Lymphatic Valve Specification By Controlling β - catenin Signaling During EmbryogenesisSemantic proximity Read

Lymph flow regulates collecting lymphatic vessel maturation in vivoSemantic proximity Read

eNOS Regulates Lymphatic Valve Specification by Controlling β-Catenin Signaling During Embryogenesis in MiceSemantic proximity Read

Rictor, an mTORC2 Protein, Regulates Murine Lymphatic Valve Formation Through the AKT-FOXO1 SignalingSemantic proximity Read

Piezo1 incorporates mechanical force signals into the genetic program that governs lymphatic valve development and maintenanceSemantic proximity Read

FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculatureSemantic proximity Read