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Article

Native CRISPR-Cas-Mediated Genome Editing Enables Dissecting and Sensitizing Clinical Multidrug-Resistant P. aeruginosa.

Cell reports - 5 Nov 2019

Xu Zeling, Li Ming, Li Yanran, Cao Huiluo, Miao Lu, Xu Zhaochao, Higuchi Yusuke, Yamasaki Seiji, Nishino Kunihiko, Woo Patrick C Y, Xiang Hua, Yan Aixin

Abstract excerpt

Despite being fundamentally important and having direct therapeutic implications, the functional genomics of the clinical isolates of multidrug-resistant (MDR) pathogens is often impeded by the lack of genome-editing tools. Here, we report the establishment of a highly efficient, in situ genome-editing technique applicable in clinical and environmental isolates of the prototypic MDR pathogen P. aeruginosa by...

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PMID: 31693906
DOI: 10.1016/j.celrep.2019.10.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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