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A genome-wide screen in <i>Pseudomonas aeruginosa</i> identifies genes impacting production of the hemolytic phospholipase C/sphingomyelinase, PlcH

2026-04-24

Abstract excerpt

The secreted phospholipase C/sphingomyelinase, PlcH, is the heat-labile hemolysin of Pseudomonas aeruginosa and one of its important secreted virulence factors. While there are known and suspected genes that impact PlcH production in P. aeruginosa , we sought to identify additional genes by screening the PA14 transposon mutant library to measure extracellular PlcH enzyme activity induced by choline. The library...

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Literature Corpus work
1aa46e1d-86f6-5dc8-a1c2-17d2322be990
DOI
10.64898/2026.04.23.720442
Open publication

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