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Directed Differentiation of Human Induced Pluripotent Stem Cells into Fallopian Tube Epithelium

31 Aug 2017

Abstract excerpt

The fallopian tube epithelium (FTE) has been recognized as a site of origin of high-grade serous ovarian cancer (HGSC). However, the absence of relevant in vitro human models that can recapitulate tissue-specific architecture has hindered our understanding of FTE transformation and initiation of HGSC. Here, induced pluripotent stem cells (iPSCs) were used to establish a novel 3-dimensional (3D) human FTE organoid...

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PMID: 28878359
DOI: 10.1038/s41598-017-05519-2

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