Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rational Design and Development of Selective BRD7 Bromodomain Inhibitors and Their Activity in Prostate Cancer

8 Aug 2023

Abstract excerpt

Bromodomain-containing proteins are readers of acetylated lysine and play important roles in cancer. Bromodomain-containing protein 7 (BRD7) is implicated in multiple malignancies; however, there are no selective chemical probes to study its function in disease. Using crystal structures of BRD7 and BRD9 bromodomains (BDs) bound to BRD9-selective ligands, we identified a binding pocket exclusive to BRD7. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Multiple Myeloma Research and Treatments
Share to Peptidase Inhibition and Analysis
Share to Protein Degradation and Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37552884
DOI: 10.1021/acs.jmedchem.3c00671

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rational Design and Development of Selective BRD7 Bromodomain Inhibitors and Their Activity in Prostate CancerPMID 37552884Read ↗

Disrupting Acetyl-Lysine Recognition: Progress in the Development of Bromodomain InhibitorsSemantic proximity Read ↗

Targeting bromodomain-containing proteins: research advances of drug discoverySemantic proximity Read ↗

Chemical Epigenetics: The Impact of Chemical and Chemical Biology Techniques on Bromodomain Target ValidationSemantic proximity Read ↗

Bromodomains as therapeutic targets in cancerSemantic proximity Read ↗

Small-Molecule BET Inhibitors in Clinical and Preclinical Development and Their Therapeutic PotentialSemantic proximity Read ↗

Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain FamilySemantic proximity Read ↗

BRD4 in physiology and pathology: ‘‘BET’’ on its partnersSemantic proximity Read ↗

Functions of bromodomain-containing proteins and their roles in homeostasis and cancer.Semantic proximity Read ↗

Design and Synthesis of a Highly Selective and In Vivo-Capable Inhibitor of the Second Bromodomain of the Bromodomain and Extra Terminal Domain Family of ProteinsSemantic proximity Read ↗

The BRD4-nucleosome interaction is enhanced modestly and non-selectively by histone acetylationSemantic proximity Read ↗

Chemical biology. A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes.Semantic proximity Read ↗

Clinical progress and pharmacology of small molecule bromodomain inhibitorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.