Article
Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells.
Molecular cancer therapeutics - 1 Feb 2009
Gallia Gary L, Tyler Betty M, Hann Christine L, Siu I-Mei, Giranda Vincent L, Vescovi Angelo L, Brem Henry, Riggins Gregory J
Abstract excerpt
A commonly activated signaling cascade in many human malignancies, including glioblastoma multiforme, is the Akt pathway. This pathway can be activated via numerous upstream alterations including genomic amplification of epidermal growth factor receptor, PTEN deletion, or PIK3CA mutations. In thi...
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