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DNA methyltransferase inhibitors combination therapy for the treatment of solid tumor: mechanism and clinical application

27 Aug 2021

Abstract excerpt

DNA methylation, an epigenetic modification, regulates gene transcription and maintains genome stability. DNA methyltransferase (DNMT) inhibitors can activate silenced genes at low doses and cause cytotoxicity at high doses. The ability of DNMT inhibitors to reverse epimutations is the basis of their use in novel strategies for cancer therapy. In this review, we examined the literature on DNA methyltransferase...

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PMID: 34452630
DOI: 10.1186/s13148-021-01154-x

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