Article

Activation of STING due to COPI-deficiency

2020-07-09

Abstract excerpt

COPA syndrome is caused by loss-of-function mutations in the COP-α subunit of coatomer protein complex I (COPI), which participates in retrograde vesicular trafficking of proteins from the Golgi to the endoplasmic reticulum (ER). Disease manifests early in life with arthritis, lung pathology, kidney dysfunction and systemic inflammation associated with NF-κB activation and type I interferon (IFNαβ) production. Her...

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Literature Corpus work: e054cf43-e40f-594a-a967-c43be9dc3bb2
DOI: 10.1101/2020.07.09.194399

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