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Article

Homeostatic regulation of STING by Golgi-to-ER membrane traffic

2020-05-21

Abstract excerpt

Coat protein complex I (COP-I) mediates the retrograde transport from the Golgi to the ER 1,2 . Mutation of the COPA gene, encoding one of the COP-I subunits (α-COP), causes an immune dysregulatory disease (COPA syndrome) 3 . The molecular mechanism by which the impaired retrograde transport results in autoinflammation is not understood. Here we report that STING 4 , an innate immunity protein, is a cargo of t...

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Identifiers and source

Literature Corpus work
72ec3b95-5eec-5c2e-b16c-5fe23e48c747
DOI
10.1101/2020.05.20.107664
Open publication

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Homeostatic regulation of STING by Golgi-to-ER membrane trafficDOI 10.1101/2020.05.20.107664
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