Article

The structure, redox chemistry and motor neuron toxicity of heterodimeric zinc-deficient SOD1-Implications for the toxic gain of function observed in ALS

2025-09-10

Abstract excerpt

<h4>ABSTRACT</h4> A subset of familial cases of amyotrophic lateral sclerosis (fALS) are caused by mutations to copper, zinc superoxide dismutase (Cu, Zn SOD1). There are over 200 mutations to SOD1 that have been associated with fALS and the majority of these mutations are dominantly inherited. Thus, individuals are heterozygous and express both wild-type SOD1 and the mutant form of the protein. Paradoxically, wh...

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Literature Corpus work: d96e8aab-4313-5578-8bc0-401e95156997
DOI: 10.1101/2025.09.10.675162

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