Article

Frequent loss-of-heterozygosity in CRISPR-Cas9-edited early human embryos

2020-06-05

Abstract excerpt

CRISPR-Cas9 genome editing is a promising technique for clinical applications, such as the correction of disease-associated alleles in somatic cells. The use of this approach has also been discussed in the context of heritable editing of the human germline. However, studies assessing gene correction in early human embryos report low efficiency of mutation repair, high rates of mosaicism and the possibility of unin...

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Literature Corpus work: e6df0390-53ef-5996-bb2f-889d029a6915
DOI: 10.1101/2020.06.05.135913

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