Article

In silico prediction, Characterization, Docking studies and Molecular dynamics simulation of human p97 in complex with p37 cofactor

2022-03-03

Abstract excerpt

<h4>Background: </h4> The AAA + ATPase p97 is an essential unfoldase/segragase involved in a multitude of cellular processes. It functions as a molecular machine critical for protein homeostasis, homotypic membrane fusion events and organelle biogenesis during mitosis in which it acts in concert with cofactors p47 and p37. Cofactors assist p97 in extracting and unfolding protein substrates through its ATP hydrolys...

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Literature Corpus work: a7fb87be-3e0e-57b3-8e80-9c7fc01d5cb7
DOI: 10.21203/rs.3.rs-1169004/v1

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