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Article

Altered intersubunit communication is the molecular basis for functional defects of pathogenic p97 mutants.

The Journal of biological chemistry - 20 Dec 2013

Tang Wai Kwan, Xia Di

Abstract excerpt

The human AAA ATPase p97 is a molecular chaperone essential in cellular proteostasis. Single amino acid substitutions in p97 have been linked to a clinical multiple-disorder condition known as inclusion body myopathy associated with Paget's disease of the bone and frontotemporal dementia. How the mutations affect the molecular mechanism that governs the function of p97 remains unclear. Here, we show that within...

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Identifiers

PMID: 24196964
DOI: 10.1074/jbc.M113.488924
PMCID: PMC3868774

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Altered intersubunit communication is the molecular basis for functional defects of pathogenic p97 mutants.PMID 24196964Read ↗

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D1 ring is stable and nucleotide-independent, whereas D2 ring undergoes major conformational changes during the ATPase cycle of p97-VCP.Semantic proximity Read ↗

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